Against the Grain: The nutritional impact of dietary gluten avoidance in the Canadian population

Celiac disease, non-celiac gluten sensitivity, wheat allergies and dietary gluten avoidance for other reasons appear to be on the rise in Canada. However, prior to the recently released Canadian Community Health Survey, there has never been an opportunity to investigate dietary gluten avoidance using recent, representative survey data collected throughout Canada. It is important to […]

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Bacteriophage Endolysin Proteins Development

In response to the antimicrobial resistance crisis, several nations (including Canada, U.S., and Europe) have drastically limited the use of medically important antibiotics for livestock production. As a result, alternative methods must be explored for disease prevention and treatment in animals from bacterial infections. The intern will explore the effects of using toxic proteins that […]

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Systematic development of novel peptide-derived therapeutics for the inhibition of lysine-modifying enzymes for the treatment of cancer

Cancer will affect 2 in every 5 Canadians in their lifetime, with just over 25% representing new breast cancer diagnoses in women. Despite significant progress in the treatment of the most common cancer in women, resistance to chemotherapeutic agents remains a consistent obstacle in terms of the successful treatment of many types of breast cancers. […]

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Characterization of the lateral hypothalamic neural outputs using camera-based multi-fiber photometry

Understanding how brain processes information is the one of the most intriguing questions that modern neuroscience faces. This project is aimed to characterize how the lateral hypothalamus process information to downstream brain targets to guide proper behavioral responses. This brain area is well-known to regulate key aspects of the behavior. But how does it process […]

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Advancement of Hyperimmune candidates against select pathogens from the Antibody Therapeutics Business Unit’s Lead Generation Program

At Emergent BioSolutions our vision is to “Protect and Enhance Life”. The Antibody Therapeutics Business Unit focuses on applying immunotherapies to prevent and treat human infectious diseases. This includes finding effective strategies to meet existing and emerging threats to public health and intentional biothreats. As part of these efforts the Lead Generation Program was created […]

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The role of Peyer’s patches in mycotoxicity

Mycotoxins are toxic metabolites from mold that commonly contaminate cereal and livestock feed crops around the world. The consumption of mycotoxins contributes to substantial economic losses to the livestock industry due to reduced productivity and health. There are over 500 different classes of mycotoxins, many of which have unknown mechanisms of action (MOA). Adding mycotoxin […]

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Industrial application of genomics derived biomarkers of salmon performance

The Atlantic salmon aquaculture industry is becoming a strategic economic sector for Canada. Aquaculture in Canada employs approximately 25,000 people with a total economic impact of over $5B. While farmed salmon is already Canada’s top aquaculture export, salmon aquaculture has significant capacity for growth in this country. Atlantic salmon farmed in sea cages on the […]

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Validation of Selective Phytocannabinoids Using In Vitro Glaucoma Models

Glaucoma is the second leading cause of blindness in the world, mainly induced by increased pressure in the eye. Marijuana has been shown to reduce such pressure, thus benefit glaucoma patients. In the previous project, we screened several individual components from marijuana extracts and tested their ability on keeping cells alive. The current project puts […]

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Development of a tissue culture platform to investigate piscine orthoreovirus infectious cycle in-vitro

The aquaculture industry is constantly growing worldwide. Vast arrays of fish species are farmed in freshwater, brackish, and marine systems. In farms, fish reach high-population densities, which facilitates the outbreaks of infectious diseases. This is a big challenge for the aquaculture industry, particularly in the case of viral pathogens because there are few, if any, […]

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Eye movement behaviours predict decision-making

Much is known about how our mind guides our attention as we visually process our environment. Visual search is guided by a marriage between internal (i.e., our explicit goals and objectives) and external (i.e., physical properties of objects) factors that influence our perception of the world around us. Recent work has shown that individuals vary […]

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Towards creating intelligent heat stress monitoring and management solutions to safeguard health and wellness

The scientific challenge for this research project is to advance our understanding of the impacts of heat stress in heat vulnerable workers and to use this information towards the creation of intelligent heat stress monitoring and management solutions to safeguard health and wellness. Currently, our understanding of the effects of heat exposure on vulnerable individuals […]

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