Mycobacterium tuberculosis is a causative agent of tuberculosis (TB) in humans. World Health Organization (WHO) conforms that, TB is one of the leading causes of death worldwide. Mycobacterium cell wall is composed of a complex, formed by peptidoglycan, lipid mycolic acid, and polysaccharide arabinogalactan. Arabinogalactan (AG) is a heteropolysaccharide that comprises of arabinose and galactose […]

A concussion is a mild traumatic brain injury (mTBI) that causes short-lived impairment of neurological function caused either by a direct blow to the head, face, neck, or elsewhere on the body with an impulsive force transmitted to the head that may or may not involve loss of consciousness. These injuries are increasing both in […]

Long dsRNA is produced by viruses during their replicative cycle. In plants and invertebrates, long dsRNAs block crucial cellular processes through RNA interference (RNAi). In vertebrates, long dsRNA is a potent inducer of critical signaling proteins that regulate antiviral immune responses. Although the RNAi system is conserved in vertebrates, there is little evidence to suggest […]

The Endogenous retrovirus-K (ERVK) group are retroviruses which are found in human DNA and are linked to the disease Amyotrophic Lateral Sclerosis (ALS). Research has found that ERVK is more active in the brains and spinal cords of ALS patients. ALS is a disease that results in a patient’s gradual paralysis and for which there […]

In schools, sounds and noise can affect the students’ and the teachers’ well being. They are constantly exposed to noise and the latter can create a sound environment that is inadeqaute for the students to study and concentrate properly. This project will explore potential benefits of visual and auditory design to establish with minimal budget […]

ALS (amyotrophic lateral sclerosis) is an incurable neurodegenerative characterized by the dysfunction and then death of motor neurons due to misfolded proteins. While healthy cells are equipped with a defence mechanism against protein misfolding known as protein quality control, it is possible that some neurons in ALS lose this mechanism. It is unknown why TDP-43 […]

Operant chambers equipped with touchscreens are a new technology that has been used for the mass behavioural phenotyping of rodent models of neurological disease. These chambers have the potential to make behavioural testing more reliable, faster, and translationally valid to human cognitive testing. To further increase the utility of these systems, technology capable of tracking […]

The number of Canadians living with diabetes is at an all-time high as are the consequential healthcare costs. A scalable solution to this public health crisis is needed. The aim of this research project is to evaluate Transform, a digital health program created by Blue Mesa Health. The program is designed to prevent diabetes by […]

Emphysema, a lung disease that millions of Canadians currently suffer from, has few safe and non-invasive options available. One of the features of emphysema is the lack of proper blood flow in the diseased lungs and this results in poor gas exchange. IKOMED Technologies Inc. has been developing a new technology that has the potential […]

Portable ladders are used by workers in industries such as construction, electrical, and telecommunications. A new powered and automated cargo management system, the RazerLift, has been designed to assist workers during portable ladder lifting tasks. The objective of this study is to investigate whether this system improves the biomechanical variables of workers during ladder lifting […]

Osteogenesis imperfecta (OI) is a heritable disorder that causes bone fractures. The drugs that are used at present help to decrease the number of fractures by about half, but most people with OI have many fractures despite receiving currently available treatments. Mesentech Inc has developed a new drug that has shown a strong effect on […]

The energetic cost of traversing the environment is a fundamental component of an animal’s energetic balance and subsequently, their body condition. Polar bears (Ursus maritimus) occupy dynamic sea ice habitats, which result in spatiotemporal variation in their energetic costs of movement. My objective is to evaluate the role of energetic balance in governing polar bear […]