Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

Bladder Carcinoma (BC) is the fifth most common cancer in Canada. Although most individuals have surgery to remove BC tumors, the risk of another BC developing and/or progressing to invasive disease is high so long-term surveillance is necessary. The current method for screening for BC is not sensitive enough, and individuals often end up undergoing […]

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that […]

Hearing aids are now fully digital, advanced signal processors. Studies show that the sound quality of today’s hearing aids is important, and may impact how a hearing aid user enjoys music. Few tools are available for clinicians to measure hearing aid sound quality in daily practice. In this project, we will develop and implement a […]

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing […]

The way a vaccine performs after injection is not completely understood and not all vaccines behave in the same way. To make a vaccine we must understand what is important or critical to make it work. For example a vaccine may have specific features such as its size or shape that are critical to the […]

Bone marrow transplantation is an effective treatment for blood-related malignancies. However, it frequently results in graft-versus-host disease (GvHD), a life-threatening condition where donor immune cells attack host tissue. It is due to individual genetic differences, present even when the donor is closely related, and results in damage to several organs including skin, liver and digestive […]

Avian Reovirus (ARV) is an economically important virus that is affecting poultry flocks in Alberta. Birds infected with pathogenic ARV may develop a disease named viral arthritis/tenosynovitis which is characterised by lameness, swollen joints, rupture of tendons and increase mortality. The disease is controlled by parent stock vaccination with live and/or inactivated antigen to provide […]

Quejos Ancient Foods (QAF) Inc. manufactures a line of dough-based food products that are gluten-free, grain-free, yeast-free, sugar-free. The dough is made from cassava flour, which has high concentration of carbohydrates and is rich in micronutrients. Traditionally, the cassava flour undergoes fermentation without the addition of yeast before the dough is made, and this process […]