Cibler l’aneuploïdie dans le cancer épithélial de l’ovaire par la modulation de la GTPase Ran. Implications thérapeutiques – Year two

Au Canada, le cancer de l’ovaire est le deuxième cancer gynécologique le plus commun. Étant donné que cette maladie est asymptomatique pendant les stades précoces, plus de 70% des patientes sont diagnostiquées à des stades avancés. Le but de notre projet est de proposer de nouvelles options thérapeutiques du cancer de l’ovaire. Il est établi […]

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Développement d’une SnapChip multiparamétrique pour l’étude du diabète

Une bonne compréhension de la biologie derrière le développement du diabète de type II est indispensable à son traitement. Malheureusement, c’est une maladie complexe dans laquelle de multiples protéines sont impliquées dans le maintien du taux de sucre dans le sang, débalancé lors du diabète. Il existe différentes approches, dites « multiplex », pour mesurer […]

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Impacts of tidal turbines on marine mammals

Canada’s coastal regions are an excellent source of marine renewable energy. These regions are also popular with marine mammals, providing good feeding opportunities. However little is known about how marine mammals will be affected by tidal energy developments. Concerns include the impacts of sound on animals’ ability to find food and navigate, the indirect effects […]

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Impacts of tidal turbines on marine mammals – Year two

Canada’s coastal regions are an excellent source of marine renewable energy. These regions are also popular with marine mammals, providing good feeding opportunities. However little is known about how marine mammals will be affected by tidal energy developments. Concerns include the impacts of sound on animals’ ability to find food and navigate, the indirect effects […]

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Engineering fucoidan synthesis

Surgical adhesions can form after many kinds of surgery, and affect millions of patients every year, hindering healing and causing pain and infertility. ARC Medical Devices has shown that treating a surgical site with fucoidan, a polysaccharide extracted from some types of seaweed, greatly reduces surgical adhesions in animals, but a source of pure fucoidan […]

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Appropriate Neuromuscular Rolling Intensities and Applications

Prior research has shown that rolling muscles can increase flexibility without performance decreases. These studies have used a variety of rolling pressures (intensities). It is not known whether higher or lower rolling pressures are better for improving flexibility. Thus one of the studies will examine different pressures of rolling on flexibility and muscle performance. On […]

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Developing Grassland Songbird Management Targets for Multi-Species Conservation on Mixed-grass Prairie Rangelands

The goal of this project is to develop management targets for grassland songbirds on native rangelands in western Saskatchewan. This research will identify grassland conditions required by priority species and examine how these differ between species and throughout prairie regions with very different soil and moisture conditions. Because native rangelands that are used for forage […]

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Validation of food allergen analytical methods and their incorporation in food process control practices – aiming for more predictable, risk-based quality management systems for processed foods

The planned research aims to validate food allergen and gluten testing tools, and their incorporation in novel quality-management systems used in food production. It will leverage existing methodologies developed by r-Biopharm Canada (r-BPC), over the past decade through its parent company. Beyond a contribution to the validation and enhanced application of these methods on various […]

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Development of a method using immuno-Raman for the simultaneous imaging of 15 biomarkers for immunotherapy of breast cancer.

We propose a novel approach that will provide researchers with an improved method to study multiple molecules, simultaneously in the same tissue section. Our strategy is to use novel nanoparticles that each emit unique multispectral signature and can be used simultaneously. We aim to develop a novel method to detect 15 breast cancer and immunotherapy-related […]

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Predicting noise impact on fish communities in the western Canadian Arctic using Passive Acoustic Monitoring

Several fish species produce species-specific sounds that can be identified in the wild using Passive Acoustic Monitoring (PAM) (i.e. dataloggers configured with underwater microphones). Our project will use existing and new PAM recordings to monitor the distribution of several fish species in the western Canadian Arctic, with particular focus on a keystone Arctic species, the […]

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Predicting noise impact on fish communities in the western Canadian Arctic using Passive Acoustic Monitoring – Year two

Several fish species produce species-specific sounds that can be identified in the wild using Passive Acoustic Monitoring (PAM) (i.e. dataloggers configured with underwater microphones). Our project will use existing and new PAM recordings to monitor the distribution of several fish species in the western Canadian Arctic, with particular focus on a keystone Arctic species, the […]

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