An in vitro Platform of Antigen-Presenting Cells to Evaluate Critical Quality Attributes in Vaccine Formulations

Sanofi-Pasteur is developing new vaccine formulations that need to be evaluated on their efficacy and potency. Traditionally, the use of animal models to predict human immunity has been accepted as the best way to select vaccine formulations. However, animal models can be costly and time-prohibitive, and the assays employed to assess vaccine efficacy and potency […]

Read More
Joint Perception and Motion Prediction System for Autonomous Vehicles

The project is concerned with delivering a real-world joint perception prediction and tracking system that outperforms the current system implemented in the Uber ATG software stack. This will be achieved by implementing a production version of a state-of-the-art academic paper developed by the research team, testing it against real world scenarios, and then modifying the […]

Read More
Local Growth Factor Presentation by Macrophages

Fibrosis comprises different connective tissue disorders that ultimately result in deposition of detrimental scar tissue in injured or inflamed organs. The culprit cells for organ scarring are called myofibroblasts because they secrete fibrous collagen matrix (“fibro”) that is contracted (“myo”) into scar tissue. Excessive myofibroblast activities are responsible for loss of function of vital organs […]

Read More
Quantum autoencoder as storage device

The Quantum Autoencoder was proposed as a device which can compress quantum states efficiently. One possible application on near term quantum devices would be the compression of quantum data in order to protect it from decoherence effects. The compression however, also introduces noise to the quantum states so that it will not always be beneficial […]

Read More
High Energy, Range extending battery for Electrical Vehicles (HERA-EV)

We can deal with the daunting challenges of depleting fossil fuels as-well-as the toxic and greenhouse gases emitted from the gasoline/diesel driven vehicles by replacing their internal combustion engine with rechargeable batteries. This project focuses on the development of an all-metal-free and biocompatible rechargeable battery system that will compete with the existing counterparts (Lithium-ion batteries, […]

Read More
Population Health Assessment Bridge for Ontario (PHABIO)

“The purpose of this project is to develop a web-based reporting system to provide central analytics for key public health indicators in Ontario. This project will enhance the capacity of health units to fulfill the foundational standard of the Ontario Public Health Standards. The project will also provide an opportunity to engage and establish partnerships […]

Read More
Open Air Interface for 5G and Beyond Cellular Networks

This research will focus on the design of 5G networks to provide for future wireless services include the use cases of Enhanced Mobile Broadband (eMBB), Massive Machine Type Communication (mMTC), and Ultra-reliable and Low Latency Communications (URLLC), and application area use cases such as Smart City, Smart Home/In-building, Augmented Reality, Self-Driving Cars, etc. 5G Technology […]

Read More
Identification of markers of lithium response in bipolar disorder

Lithium is one of the oldest psychiatric drugs and remains the first-line treatment in the management of bipolar disorder. Studies show that lithium can significantly reduce suicide risk and also help prevent future manic and depressive episodes. As a result, it may be prescribed for long periods of time as maintenance therapy. However, clinical response […]

Read More
Photoactivated Cell Migration in 3D-Printed Tissue Scaffolds

The project aims to develop a novel research tool that simulates the cell’s natural 3-dimensional environment, while providing the researcher with dynamic control of said environment. This tool will elicit natural cell responses (ie. In tissue), unlike conventional 2-dimensional cell cultures. The tool will also provide the researcher with precise control over the mechanical/biochemical cues […]

Read More
Identifying and validating rational combinatorial therapies for treatment-refractory Glioblastoma

Glioblastoma (GBM), the most common and deadly form of primary brain cancer in adults. After diagnosis, GBM patients undergo standard therapy, including surgery, chemotherapy and radiation therapy. Unfortunately, disease relapse is inevitable and patients face a median survival of less than 15 months. A small population of tumor cells, known as brain tumor initiating cells […]

Read More