We combine quantitative experimental measurements of immune cells with mathematical models to systematically study the body’s anti-viral response. In particular, we are looking at how immune cells communicate with each other to coordinate an immune response. We want to understand how biochemical reactions in the cell can be used to process the complicated pattern of […]

Through a pre-post design, I will examine the impact of UL rehabilitation followed by UL rehabilitation combined with BT on arm function. Patients with stroke and spasticity are unique; thus, the effect of BT is specific and it is difficult to compare groups of subjects. Using subjects as their own control is the most suitable […]

Working memory impairments are a common co-morbidity of pediatric epilepsy and adversely impact school performance and quality of life. Research in adults with temporal lobe epilepsy suggests that brain networks established in long-term memory (i.e., hippocampus in the mesial temporal lobe) may be involved in working memory, but it is not yet known whether these […]

The objective of this project is to apply machine-learning algorithms for the assisted computational search of new energy materials. In particular, cathodes for Li-ion batteries and solid-electrolyte interphase systems will be explored. Development of new high-performance battery materials is an integral component of overcoming the dependence on fossil fuels and ending the energy and climate […]

Differences in our genes can increase or decrease susceptibility to certain diseases and influence response to drugs. Pharmacogenomics is the study of how genetic variation impacts efficacy and toxicity of drugs. To date there are more than 1200 pharmacogenes described in literature, but only a small fraction of them have been implemented into clinical practice […]

This research project seeks to develop new low-cost and abundant materials for energy storage, like batteries, with an improved performance. The work will include the design, synthesis and characterization of the new materials, and, ultimately, will use them in fully functional devices. The project will focus in novel ways of combining elements and alloys with […]

Adult onset diabetes, or type 2 diabetes, is becoming more common in Canada and across the world. And it is a risk factor for stroke. For example, silent strokes lesions are common in adults with type 2 diabetes. Despite this knowledge, we do not have a very good understanding as to how type 2 diabetes […]

Patients with coronary artery disease often present clinically with a cluster of vascular risk factors, which predispose them to stroke and can cause subtle deficits in cognitive performance. These deficits are believed to pertain, in part, to disease of the small blood vessels providing blood to the brain. Fitness is associated with better cognitive performance, […]

Given the current global environmental crisis, developing sustainable solutions to enhance or replace our current agricultural practices is critical: the agricultural sector exerts important environmental pressure through its aggressive land, water and pesticide usage combined with the ever increasing demand on food supply. Mitigating this problem requires developing more sustainable and efficient agricultural techniques. Precisely, […]

Preliminary work has shown that adding excess CEACAM1-specific antibody, 26H7, to hela cells expressing carcinoembryonic-antigen-related cell-adhesion moleule (CEACAM) 1-4L decreases CEACAM1-4L in the plasma membrane and shifts their surface expression from a monomer-oligomer mix to mainly monomers. A super resolution microscope will be used to co-localize CEACAM1-4L with 26H7 in order to determine the optimal […]

Assessment of surgical data from an operating room is a complex process that may require significant resources such as expert input and advanced technology. Automation brings a considerable opportunity to greatly reducing these significant resource requirements – e.g., using computer vision software to detect clinically relevant actions during surgery. However, those detections should be interpretable, […]

Heat exchangers, used in building heating, ventilation and air conditioning (HVAC) systems to transfer heat from hot to cold fluids, are designed to operate under ideal conditions. However, in practice operating conditions may vary with ambient temperature or humidity. HVAC system efficiency can be improved significantly if fluid flow rates are adjusted in response to […]