Designing cross-species-reactive compact promoters for targeting specific cell types in the body

The interns will first conduct market research to determine the demands of the current life sciences industry, including pharmaceutical companies, gene therapy development companies, and companies that offer transgenic animal models. With this data, the interns will work together using a proprietary machine-learning algorithm from Re:Pair Genomics to design a catalog of 5-10 different compact, […]

Read More
Towards Trustworthy AI in Dementia Care: Enhancing Anomaly Detection with Uncertainty-Aware Modeling for Aging in Place

This project aims to improve a home-based reminder system that supports people living with dementia and their caregivers. The system, called Remindful, uses artificial intelligence (AI) to detect unusual changes in daily routines that may signal health concerns. This research will make the system more trustworthy by adding features that show how confident the AI […]

Read More
Characterization of TEC kinase small molecule compounds

Peripheral T-cell lymphoma (PTCL) is a type of blood cancer with poor treatment outcomes, as patients often relapse or do not respond to available therapies. A key factor driving the growth of cancerous T cells in PTCL is a protein called ITK, which helps these cells survive by activating biological pathways that boost cell growth […]

Read More
Biophysical and Structural Characterization of Peptide Macrocycle-based Huntingtin Degraders

Huntington’s Disease (HD) is a debilitating neurodegenerative disease marked by progressive loss of motor control and cognitive function. Presently, there are no disease-modifying therapies. A potential avenue for slowing or stopping HD progression is to target huntingtin (HTT), or polyglutamine-expanded mutant HTT (mHTT), for degradation using proteasome targeting chimera (PROTAC) technology. A PROTAC will bring […]

Read More
Addressing Cardiac Conductive Disturbances Following TAVI Procedures: Optimizing Post-Procedure Care

Cardiac conduction disturbances (CDs) are a prevalent complication of transcatheter aortic valve implantation (TAVI) procedures, which are performed by interventional cardiologists to treat heavily calcified aortic valves. CDs may emerge during or after TAVI, and are typically caused by mechanical injury to the heart’s conduction system, which can be highly challenging to prevent during the […]

Read More
Novel product and prototype development for soft tissue regeneration

Gingival recession affects ~50% of the population and results in the exposure of tooth root surfaces, which leads to an increased risk of dental caries. The gold standard treatment is autologous grafts involving tissue being harvested from the roof of a patient’s mouth, leading to pain and bleeding, the inability to eat, risk of infection, […]

Read More
Characterizing the relationship between infrared thermography of bony prominences occluded by lower limb orthopedic casts and local skin integrity in hospitalized children with disabilities

This project aims to improve the early detection of pressure injuries (PIs) in children with disabilities who wear casts for long periods. PIs occur when continuous pressure over bony areas damages the skin, leading to pain, infections, and longer hospital stays. Currently, it is difficult to monitor the skin under a cast because it cannot […]

Read More
A microfluidic platform for clinical sperm selection

We propose to develop a microfluidic device that enables the selection of viable sperm directly from semen via a simple dip approach. The device will feature a chamber incorporating a porous membrane. The sperm selection method involves only two steps – users load the device with a semen sample and place the device in buffer. […]

Read More
Oculomotor function in adults with concussion: A synthesis of evidence and clinical trial

Concussions are a frequently occurring injury with diverse clinical manifestations and an often-challenging recovery. Oculomotor deficits are commonly occurring in persons with concussion, both as an early symptoms and impairment long after the injury. Early assessment and rehabilitation of oculomotor deficits resulting from concussion have the potential to expedite recovery and improve affected individuals’ functioning. […]

Read More
Improving polymer-encapsulated nanoparticle assembly and delivery towards applications in agriculture, with positive environmental impact

Nanoparticles are objects on the scale of billionths of a meter, and their small size gives them properties that are scientifically interesting and commercially important. Vive Crop Protection has commercialized a technology in which they use a nanoparticle-enabled approach to enhance the delivery of agricultural pesticides. This project is about controlling the process of clumping […]

Read More
M.I. Understanding Social Platform Strategy Optimization

M.I. Understanding is a community-centered educational organization that supports families, caregivers, educators, and children as they navigate important social and developmental challenges. Through online learning modules, original puppeted educational videos, and curated guidance to external supports, the organization builds understanding around childhood mental health, PRIDE education, and an upcoming expansion into Fetal Alcohol Spectrum Disorder […]

Read More