Well-Defined Silica-Supported Titanium Catalysts for Introducing Nitrogen Functional Groups

Nitrogen is a key component in many molecules used as medicines, materials and fertilisers. Adding nitrogen into molecules is currently inefficient and expensive: it requires multiple steps and creates a lot of waste. Alternatively, it is possible to introduce nitrogen by processes called hydroamination and hydroaminoalkylation. These reactions are 100% atom efficient (all of the […]

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Étude des effets cognitifs et physiologiques de la prise de retraite

L’augmentation de l’espérance de vie et le recul de l’âge moyen de départ à la retraite font que le temps passé à la retraite est plus important qu’auparavant. La prise de retraite pourrait accélérer le déclin cognitif associé au vieillissement. Or, un mode de vie caractérisé par une activité physique élevée et un faible niveau […]

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Genre et migration : portraits de l’émergence des renégociations militantes en temps de crise sanitaire au Chiapas

J’explore dans ma recherche les différentes formes de solidarités et soins dans la ville de San Cristobal de las Casas ( Mexique). L’idée est de produire une analyse des modalités et des réseaux d’appui entre femmes, en incluant des espaces d’hébergement, (refuges ou espaces d’accueil) dans la région sud du Mexique. Cette région est une […]

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Caractérisation du rôle de la famille des prokinéticines dans le contrôle de la chorioamniotite et dans les conséquences neurodéveloppementales néonatales.

La chorioamniotite, infection ascendante de la grossesse est une cause majeure de prématurité et de paralysie cérébrale chez les enfants prématurés. Le laboratoire du Pr Sébire (Research Institute of McGill University Health Center, Montréal) a mis au point un modèle de rates gestantes présentant une chorioamniotite induite par du streptocoque du groupe B. Au cours […]

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Caractérisation non destructive des enrobés bitumineux

Les enrobés bitumineux sont majoritairement utilisés pour revêtir les structures de chaussée. La caractérisation de leur comportement thermomécanique est donc essentielle pour comprendre leur fonctionnement sous charge et dimensionner correctement les structures neuves ou qui doivent être réhabilitées. À l’heure actuelle, la majorité des essais qui permettent de caractériser ces matériaux en laboratoire nécessite des […]

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Engaging youth in participatory research: A trans-national Canada-France study to improve youth mental health and wellbeing in the context of the COVID-19 pandemic

The COVID-19 pandemic and corresponding health, social and economic implications have resulted in significant life changes for youth. One of the most critical impacts has been on youth mental health and wellbeing. To address the mental health needs of diverse youth populations during and following the COVID-19 pandemic, the proposed internship will advance the CIHR-funded […]

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Artificial Intelligenece to study tumor heterogeneity

High throughput multi-omic cancer studies have described the inter-tumor heterogeneity and led to well defined molecular classifications. Nevertheless, these classifications only reflect the most abundant tumor subtype in the examined sample, thus neglecting intra-tumor heterogeneity, a major source of therapeutic resistance. As advanced microdissection techniques to isolate a cell population of interest from heterogeneous clinical […]

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Novel rhamnolipids for a sustainable bioeconomy

Today’s society faces several challenges in implementing and enforcing environmental protection for future generations. In this respect, supplementation of petro-based chemicals by bio-based ones is of special importance to reduce the consumption of crude oil. Among such measures, chemical surfactants can be replaced by biosurfactants, e.g. rhamnolipids which are produced via fermentation from renewable resources […]

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Evolutionary and functional analysis of genes involved in nitrogen-fixing symbiosis as a case of convergence

A major challenge facing farmers is obtaining the nitrogen needed to support plant growth. Inoculation of legume crops with bacteria known as rhizobia, which supply plants with the required nitrogen, is a green alternative to environmentally hazardous nitrogen-fertilizers. The development of highly-efficient rhizobium inoculants is a pre-requisite for sustainable intensification of agriculture. In five clades […]

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Feasibility of individualised synthetic speech for children with complex communication needs (CCN) in three South African languages

An individual’s voice is unique due to a combination of their physical and social characteristics. For children who present with complex communication needs (CCN), sometimes the only functional way to communicate is by using an augmentative and alternative communication (AAC) device. AAC devices with speech output capability are known as voice output communication aids (VOCAs). […]

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Restoring bacterial sensitivity to aminoglycosides antibiotics

Bacterial resistance to aminoglycoside antibiotics is a major public health problem. The WHO (World Health organization) has highlighted the urgent need to find new treatments to fight multidrug resistance MDR bacteria, as actual drugs are less effective or inactive. This research project aims to develop new chemical compounds to restore bacterial sensitivity to antibiotics currently […]

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Making AI Ready for Safety-Critical Applications

This project is a collaborative endeavor of researchers (6 supervisors, 3 PhD students and one postdoctoral fellow) which will be either members or visitors of the incoming “International Laboratory on Learning Systems” (ILLS) of the CNRS (starting in early 2022) with Université Paris-Saclay, McGill University and École de technologie supérieure (ETS). We will develop rigorous […]

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