Real-time electromagnetic navigation of oral cancer resection

Breast?conserving surgery (BCS) is a mainstay in breast cancer treatment. For nonpalpable breast cancers, current strategies have limited accuracy, contributing to high tumor-positive margin rates. Perk-Lab developed NaviKnife, a surgical navigation system based on real?time electromagnetic (EM) tracking. The goal of the research project is to confirm the further feasibility of intraoperative EM navigation in […]

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Advanced Analytical Techniques integrated with Machine Learning for Proactive Raw material Characterization for Vaccine Production – Year two

Over the last several decades, challenges in the development, production, supply, and use of vaccines have been raised and by consequence had led to increasing concern around the world. As a result, an increase in research and innovation in the vaccine industry is needed. In this sense, one of the most critical factors in the […]

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3D spine imaging using tracked ultrasound and artificial intelligence

Obtaining accurate images of the spine is important for different medical purposes. For example, to measure how deformed the spine is in patients with scoliosis and select the most suitable treatment. Images can also be used to guide a clinician while inserting a needle to reach a exact location in the spine to administer anesthesia. […]

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The Application of Single Domain Antibodies in Biasing GPCR Signal Pathways – A Case Study with the Adenosine A2A Receptor

Single domain antibodies (sdAbs) represent a versatile class of heavy chain antibodies lacking a paired light chain and encoded by VHH germline genes typically expressed in camelids. KisoJi Biotech has developed a transgenic mouse line in which each mouse expresses multiple camelid VHH genes capable of specifically binding any antigen of interest. The small molecular […]

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The Application of Single Domain Antibodies in Biasing GPCR Signal Pathways – A Case Study with the Adenosine A2A Receptor – Year two

Single domain antibodies (sdAbs) represent a versatile class of heavy chain antibodies lacking a paired light chain and encoded by VHH germline genes typically expressed in camelids. KisoJi Biotech has developed a transgenic mouse line in which each mouse expresses multiple camelid VHH genes capable of specifically binding any antigen of interest. The small molecular […]

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The Narreme Engine: A Tool for Narrative Analysis and Construction

In my PhD dissertation, I proposed a renewed theory of the “narreme” – the minimum basic unit of narrative structure, a concept which originated in the 1960s but which has been largely neglected since then. I suggested that a Narreme Theoretic approach could be tremendously useful not only for the purposes of narrative analysis, but […]

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The Narreme Engine: A Tool for Narrative Analysis and Construction – Year two

In my PhD dissertation, I proposed a renewed theory of the “narreme” – the minimum basic unit of narrative structure, a concept which originated in the 1960s but which has been largely neglected since then. I suggested that a Narreme Theoretic approach could be tremendously useful not only for the purposes of narrative analysis, but […]

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Understanding the neural underpinnings of a novel PTSD therapy: Goal Management Therapy

A wide range of cognitive faculties are commonly compromised in numerous trauma-exposed populations, leading to impaired functioning, and reduced treatment response rates. There is a dire need for novel therapies that can directly target such deficits in top-down cognitive control. Goal management training (GMT) is one such cognitive remediation therapy found to be effective for […]

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Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

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Modelling Guidance for Low Impact Development Practices

To combat the degradation of receiving water resulting from stormwater runoff approaches that focus on retaining and infiltrating stormwater at the source, referred to as Low Impact Development (LID) practices, are being proposed more frequently in recent years. Toronto and Region Conservation Authority recently initiated monitoring of precipitation and runoff from a large industrial site, […]

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