Eukaryotic cells have evolved complex sub-compartments to partition the cell interior into tiny contained 3D microenvironments. The endoplasmic reticulum (ER) communicates with and regulates other intracellular structures, including the endolysosomal system, through membrane contact sites (MCSs). Dysfunction in endolysosomal spatial-temporal regulation is implicated in neurodegeneration, cancer, and metabolic disease. Recently, it was found that the […]
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