“Melanocortin 4 receptor (MC4R) is a is a G protein-coupled receptor (GPCR) and key regulator of energy homeostasis. MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The efficacy of several lead compounds on restoring the cell surface expression and function […]

“Melanocortin 4 receptor (MC4R) is a is a G protein-coupled receptor (GPCR) and key regulator of energy homeostasis. MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The efficacy of several lead compounds on restoring the cell surface expression and function […]

Ground water is the principal drinking water source in North America and approximately 150 million people relies on ground water for their domestic supply. Groundwater contamination occurs as a direct or indirect result of human or animal waste ingress to groundwater resources. The anthropogenic activity resulted in the contamination of surface and ground water with […]

Age-based diseases of cognitive dysfunction such as dementia and Alzheimer’s are a growing problem in Canada that already cost the healthcare system over $10 billion annually. The ability to provide the general public with ubiquitous access to iterative cognitive function testing would be extremely valuable to the individual, society, and science. LRDG has commenced development […]

Age-based diseases of cognitive dysfunction such as dementia and Alzheimer’s are a growing problem in Canada that already cost the healthcare system over $10 billion annually. The ability to provide the general public with ubiquitous access to iterative cognitive function testing would be extremely valuable to the individual, society, and science. LRDG has commenced development […]

Canada ambitions to achieve a deep decarbonization of its economy by 2050, with a reduction of its greenhouse gas (GHG) emissions up to 90% relative to their 2005 levels. Such a transition from the current situation will have important impacts in particular on its energy sector. In this context, SIEMENS Canada, a manufacturer of energy […]

The use of oocytes from peri-pubertal heifers represents an important reproductive management asset, assisting with the rapid multiplication of high merit genetic material and the reduction of generation interval. However, oocytes from peri-pubertal heifers have reduced developmental capability leading to embryos of lower quality. Furthermore, the in vitro culture conditions for the embryo production were […]

There is no direct way to measure spinal loads, and existing methods are indirect and invasive; alternatively, musculoskeletal models can predict spinal loads accurately and economically. Existing musculoskeletal models of spine substantially simplify the spine and/or use optimization algorithms to estimate muscle forces. Thus, we aim to develop a subject-specific musculoskeletal model of the spine […]

There is no direct way to measure spinal loads, and existing methods are indirect and invasive; alternatively, musculoskeletal models can predict spinal loads accurately and economically. Existing musculoskeletal models of spine substantially simplify the spine and/or use optimization algorithms to estimate muscle forces. Thus, we aim to develop a subject-specific musculoskeletal model of the spine […]

L’argousier est un petit fruit nordique bien adapté au climat boréal. Son fruit, l’argouse, se distingue des autres petits fruits par la diversité de ses composés bioactifs. Il est notamment riche en caroténoïdes et en polyphénols. Notre projet vise à comparer la composition chimique des fruits de 15 cultivars d’argousier actuellement cultivés au Québec. Il […]

In the context of the “Smart Grid”, the exploitation of electricity consumption flexibilities will be a key lever in the optimization of the electric system. It can help to limit power demand peaks, increase the share of renewable energy and limit network infrastructure investments. Consumption flexibilities, which are offered by many residential consumers, are distributed […]

Lors de la réalisation de pâtes de boulangerie, les ingrédients de base sont mélangés dans de grandes cuves afin de créer un pâton qui sera ensuite mis en forme et cuit. Lors du mélange, les ingrédients se lient pour passer de poudres et liquides à une pâte épaisse et visqueuse. La température de la cuve […]