AYAZAZI

My doctoral work will leverage data from the AYAZAZI study, a longitudinal cohort study which assesses intersecting socio-behavioural, structural, and biomedical HIV risk factors among HIV-negative or HIV-status unknown youth in two South African communities, to examine the biological and psychological consequences of chronic stressors. This internship will be focused on community engagement and relationship […]

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Étudier les interactions des constituants du liquide à vapoter et des aérosols générés par la cigarette électronique avec différentes composantes de la cavité buccale

La cigarette électronique est un dispositif proposé aux fumeurs pour remplacer la cigarette standard dans le but de réduire-éliminer les effets nocifs de la fumée de cigarette. Cette cigarette électronique a été présentée comme une solution efficace de remplacement, et un moyen sans dangers pour la santé des utilisateurs. Cependant, plusieurs études récentes démontrent que […]

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Remodeling of relaxin-3 contacts on somatostatin interneurons in the amygdala of a mouse inflammatory pain model: a CLEM study with array tomography

Le projet vise à élucider les mécanismes des douleurs persistantes, et leurs conséquences sur des pathologies émotionnelles associées (anxiété). Notre hypothèse est que les modifications de l’activité des aires cérébrales impliquées dans les douleurs pathologiques et l’anxiété mettent en jeu des voies nerveuses descendantes qui relient le cortex et la moelle épinière. Le projet s’intéresse […]

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Développement et validation d’instruments de mesure auprès des populations vulnérables suisses.

Les instruments de mesure (questionnaires) qui sont complétés directement par les personnes permettent une évaluation en adéquation avec le vécu et les expériences de ces personnes. De tels instruments de mesure nécessitent cependant une évaluation approfondie par des experts afin d’assurer la validité du contenu des questions et l’association des questions avec le phénomène qu’il […]

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Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development – Year two

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

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Sensory Disinhibition, Cognitive Flexibility and the Neural Correlates Underlying Post-Traumatic Stress Disorder (PTSD): A Simultaneous EEG-fMRI Study

Individuals with post-traumatic stress disorder (PTSD) often struggle to relax, or simply be at ‘rest.’ In particular, recent research has revealed participants with PTSD show hyper-activity across the visual cortex while at rest. Referred to as sensory hyper-activity and disinhibition, altered resting-state patterns are thought to be underlying hypervigilance and re-living sensations clinically, as well […]

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Multi-scale Image integration for Surgical Guidance

During surgery, a neurosurgeon must refer to three levels of image information: macroscopic from the patient’s MRI or CT, providing anatomical context of the surgical target; mesoscopic information from a surgical microscope or exoscope providing a highly magnified view of the region surrounding the surgical target; and the most important microscopic information provided by histology […]

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Multi-scale Image integration for Surgical Guidance – Year two

During surgery, a neurosurgeon must refer to three levels of image information: macroscopic from the patient’s MRI or CT, providing anatomical context of the surgical target; mesoscopic information from a surgical microscope or exoscope providing a highly magnified view of the region surrounding the surgical target; and the most important microscopic information provided by histology […]

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Ayazazi

AYAZAZI (meaning ‘Knowing Themselves’ in Zulu) was a CIHR funded youth-centred, multi-site, interdisciplinary, prospective cohort study focused on HIV prevention among 425 adolescents and young adults (aged 16-24 years) residing in Soweto and Durban, who reported HIV-negative or unknown status at enrolment. AYAZAZI is guided by a youth engagement framework, which prioritizes youth-friendly spaces and […]

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Real-time electromagnetic navigation of oral cancer resection

Breast?conserving surgery (BCS) is a mainstay in breast cancer treatment. For nonpalpable breast cancers, current strategies have limited accuracy, contributing to high tumor-positive margin rates. Perk-Lab developed NaviKnife, a surgical navigation system based on real?time electromagnetic (EM) tracking. The goal of the research project is to confirm the further feasibility of intraoperative EM navigation in […]

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