Advanced Analytical Techniques integrated with Machine Learning for Proactive Raw material Characterization for Vaccine Production – Year two

Over the last several decades, challenges in the development, production, supply, and use of vaccines have been raised and by consequence had led to increasing concern around the world. As a result, an increase in research and innovation in the vaccine industry is needed. In this sense, one of the most critical factors in the […]

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Understanding the neural underpinnings of a novel PTSD therapy: Goal Management Therapy

A wide range of cognitive faculties are commonly compromised in numerous trauma-exposed populations, leading to impaired functioning, and reduced treatment response rates. There is a dire need for novel therapies that can directly target such deficits in top-down cognitive control. Goal management training (GMT) is one such cognitive remediation therapy found to be effective for […]

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Hyperpolarized 129Xe Cerebral Perfusion MRI Imaging Development

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

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Exploring Social Finance Opportunities in Newfoundland and Labrador

The objective of this research is to explore the many social finance tools that have been implemented by other agencies across North America, and measure their effectiveness and applicability in a Newfoundland and Labrador context. In partnership with a MUN researcher, this work would include primary data collection in the form of interviews and surveys […]

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Evaluation of the implementation at scale of a public health intervention to promote social and emotional development in the early years in British Columbia

British Columbia’s Ministry of Mental Health and Addictions has identified healthy social and emotional development (SED) in early childhood as a priority action towards addressing the province’s mental health crisis. In response, ChildHealth BC (CHBC) is developing a multi-component provincial intervention to expand the capacity of caregivers to promote SED in young children- the first […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human Mammary Cells to Enable Their Optimized Growth as Organoids Ex Vivo

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human MammaryCells to Enable Their Optimized Growth as Organoids Ex Vivo – Year two

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Development of a specific targeted therapy for hepatocellular carcinoma – Year two

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

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Optimization of Graphical User Interface for the Digital Pathology Workstation

The workflow of pathologists will soon be revolutionized with the introduction of digital pathology allowing pathologists to view tissue samples as a digital image on a computer workstation. Such a conversion from traditional microscopy will bring many benefits to the pathologist’s workflow aiming to boost significant efficiency as well as ergonomic benefits. However, much work […]

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User Feedback Evaluation and Providing Insights on UI Refinements for Refresh Wellness Application

People who experience mental wellness challenges or mental illness often struggle to obtain or maintain a position in the workplace. Furthermore, lack of employment means individuals lose out on a myriad of mental, emotional, and physiological benefits that are generated through work. This is extremely relevant given the current COVID crisis, where personal distancing and […]

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