Molecular signatures and predictive biomarkers for phenotyping allergic rhinitis responses

Allergic rhinitis (AR) is in inflammatory disease characterized by nasal symptoms. It affects 20-25% of Canadians and is recognized as the most common allergic disorder worldwide. Patients can experience one of several types of responses to allergen onset hence a key hurdle to developing effective treatment plans is accurate diagnosis. The allergic responses are characterized […]

Read More
Towards a Theory of Blockchain as a Socio-Informational-Technical System

Blockchains operate as perhaps the most promising system of trust for any type of digital transaction of value — everything from cryptocurrencies to patient medical records. But a number of barriers — involving social institutions, data and identity management and technological processes — stand in the way of broader adoption. These challenges also ultimately speak […]

Read More
Investments in social housing in Nunavut and Nunavik: impacts on the mental well-being of Inuit families

Mon projet de thèse s’intéresse aux impacts d’investissements dans le logement social sur la santé mentale de familles inuites. Il a été développé en partenariat avec plusieurs organisations inuites du Nunavut et du Nunavik qui ont identifié les conditions de logement comme étant un levier majeur pour l’amélioration des conditions de vie et de santé […]

Read More
Seizure induction by single-cell control of neural circuits

The impact of seizures on the life of an epilepsy patient is significant. How they start, propagate and terminate remains unknown. Our hypothesis is that seizures develop in the brain when populations of neurons lose their ability to efficiently parse incoming inputs, known as decorrelation. When these neurons are not able to sufficiently decorrelate incoming […]

Read More
Evaluating and optimizing rural and urban lesbian, gay, bisexual, transgender, queer, intersex, and Two-Spirit (LGBTQI2S) engagement with hospice and palliative care in the Island Health Region

Existing research focused on the experiences of gay and lesbian older adults with the health care system report that there is a general distrust and reluctance to access healthcare based upon the cumulative effect of discrimination over the life course. At present, while 75% of Canadians have indicated they would like to die at home, […]

Read More
Evaluating and optimizing rural and urban lesbian, gay, bisexual, transgender, queer, intersex, and Two-Spirit (LGBTQI2S) engagement with hospice and palliative care in the Island Health Region – Year two

Existing research focused on the experiences of gay and lesbian older adults with the health care system report that there is a general distrust and reluctance to access healthcare based upon the cumulative effect of discrimination over the life course. At present, while 75% of Canadians have indicated they would like to die at home, […]

Read More
Adaptive operating room (OR) scheduling and control

McCaig Tower, as one of the largest sites of Foothills Medical Centre, provides the world’s safest and most accurate surgeries to patients, and a SmarTrack system, an interactive patient tracking system, helps the operating room (OR) management. However, due to the dependence of ORs on pre-operative preparations and post-operative capacities, the disturbances that come from […]

Read More
Integrating First Principles and Big-Data Analytics for Improved Biomolecular Simulations

Laws of physics combined with computational prowess has allowed us to simulate biological processes at a molecular level, which have a wide range of applications which include guiding experimental observations, designing drugs with molecular precision, and improving bio-sensor technology. However, the existing models use approximations that that limit scope of their applicability, due to the […]

Read More
Health Records over Blockchains

It is hard to understate the critical role access to a patient’s comprehensive medical history plays in diagnosing (and treating) patient illness. For a doctor, knowing the latest prescribed drugs of his patient might, for example, point directly to the cause of an illness — which might be just a drug side effect. Yet patients […]

Read More
Health Records over Blockchains – Year Two

It is hard to understate the critical role access to a patient’s comprehensive medical history plays in diagnosing (and treating) patient illness. For a doctor, knowing the latest prescribed drugs of his patient might, for example, point directly to the cause of an illness — which might be just a drug side effect. Yet patients […]

Read More
Identification of blood-based biomarkers predictive of pulmonary exacerbations in cystic fibrosis

Individuals with cystic fibrosis experience recurrent episodes of worsen in respiratory symptoms, termed pulmonary exacerbations (PEx). Early identification of individuals who are at elevated risk of PEx can improve their clinical outcomes and rescue their lung function. In this project, we will collaborate with the Prevention of Organ Failure Centre of Excellence (PROOF) to develop […]

Read More
Understanding the Mechanism of Probiotics for Human Health

DoseBiome has developed a new probiotic that targets several aspects of oral health: dental caries, periodontal diseases, and halitosis. This project aims to understand the exact mechanism of our probiotic’s inhibitory properties against the pathogens associated with the above diseases. DoseBiome is a new start-up in the probiotic/microbiome health sector, and this project will allow […]

Read More