Advancement and evaluation of novel a quantitative ultrasound method for tissue characterization in dental diagnostics.

Gingival thickness (biotype) and quality of soft tissues have a significant impact on the outcome of dental restorative and regenerative therapy for many patients. Assessment of periodontal biotype is critical when selecting appropriate protocols in the field of dental surgery. Chosen methodology will have significant ramifications on the restoration of the soft and hard oral […]

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Acute effects of single arm muscle fatigue on bilateral cortical inhibition and functional connectivity

Diseases and injuries can affect essential activities of daily living like holding objects or walking. Investigating ways to optimize motor learning and performance is important for patient (i.e., stroke patients) and healthy populations (i.e., athletes). Exercising muscles to fatigue on one side of the body may improve motor tasks executed by the opposite limb. This […]

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Effects of changes in mechanical load on cardiac autoregulation in vivo

The heart beats 3-4 billion times in a person’s lifetime, making it the only part of the body that continues to work – without a break – for one’s entire existence! For this to occur, the heart must be highly regulated, so that is continues to function normally. Much of this regulation occurs within the […]

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Validity and Reliability of Ultrasonography for the Objective Assessment of Diaphragm Function in Healthy Adults

The diaphragm is the major inspiratory muscle in humans. Making accurate assessment of diaphragmatic function a key component of monitoring and assessing respiratory health. Presently, the gold-standard clinical assessment of diaphragmatic function involves measuring the pressure difference across the diaphragm using dual balloon-tipped catheters. While this technique is direct, accurate and reliable, it is also […]

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Amélioration d’oreilles artificielles dédiées à l’étude du confort acoustique et physique

Au Québec, environ 360 000 travailleurs sont exposés quotidiennement à des niveaux de bruit susceptibles d’engendrer des problèmes d’audition. Les bouchons d’oreilles individuels sont souvent utilisés pour pallier ce problème. Cependant, l’inconfort lié à l’utilisation de ces protecteurs limite leur durée d’utilisation et donc leur efficacité. L’objectif de ce projet est de concevoir des outils […]

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Résolution temporelle de détecteurs monolithiques et pixellisés pour la tomographie d’émission par positrons avec temps-de-vol ultra-rapide

La tomographie d’émission par positrons (TEP) est une modalité d’imagerie médicale permettant le diagnostic et le suivi de cancers, maladies neurodégénératives et maladies cardiométaboliques. La prochaine percée majeure en imagerie TEP repose sur la mesure de temps-de-vol (TdV) ultra-rapide, nécessitant une excellente résolution temporelle des détecteurs du scanner. Les détecteurs conventionnels ne possèdent malheureusement pas […]

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The effect of a topical analgesic on neuromuscular endurance and pain

It has been shown that topically applied gels, which contain menthol, result in a cooling sensation and reduce the sensation of pain. Because neuromuscular endurance activity leads to sweating and muscle pain we seek to discover the effect of BioFreeze on various forms of neuromuscular endurance activity and muscle soreness. This discovery will require 3 […]

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Development of an efficient process to produce influenza virus-like particles in insect cell culture platform

Vaccination is the most effective way to prevent influenza infections. However, the current production of influenza vaccines in embryonated chicken eggs has limited capacity during pandemics or high demand seasons, and is both labor-intensive and time-consuming. Consequently, there is a need to develop a robust production platform that can efficiently accelerate the production process and […]

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Evaluation of influenza virus inactivation on filter salt coatings for respiratory protection applications

Airborne pathogens can easily and quickly spread respiratory diseases. Devices currently used for protection in hospitals, such as N95 respirators, rely only on filtration. Additionally, surgical masks have been increasingly used, although not effective against aerosols. This has been observed during past pandemics and epidemics of severe acute respiratory syndrome (SARS), swine flu, and Middle […]

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Development of human recombinant GOT–polymer bioconjugates for the treatment of ischemic stroke

Glutamate, the most widespread excitatory neuromediator in the brain, plays an important role in learning and memory functions. At very high cerebral concentrations it is likely to cause pathological effects (nerve cell death), such as those encountered in ischemic stroke. To reduce the toxic concentrations of glutamate in the brain, several approaches have been developed. […]

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Effects of Chemotherapy and Immune Cells on Ribosomal RNA Degradation (RNA disruption) in Tumour Cells

The business partner in this application (Rna Diagnostics, Inc.) has developed a diagnostic tool to determine whether the tumour(s) of a cancer patient undergoing chemotherapy before surgery is responding (dying) in response to treatment. This tool, called the Rna Disruption Assay (RDA), can help tailor chemotherapy, such that chemotherapy treatment is discontinued (along with its […]

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