Développement et validation de nouvelles cibles épigénétiques de la douleur chronique chez l’animal arthrosique – Year two

La douleur arthrosique est la première cause de morbidité et de douleur chronique dans nos sociétés occidentales, source de pertes économiques et de productivité énormes. L’arthrose est aussi la maladie dégénérative la plus commune chez les animaux de compagnie et un sujet de consultation vétérinaire fréquent. Malgré des analyses extensives, l’origine et le développement de […]

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Evaluating Natural Channel Design Performance in Southern Ontario

Natural channel design practices are continually evolving, but monitoring the performance and success of these urban river engineering projects is often limited to sparse point measurements of streamflow, stream morphology, and species inventories during the 2 – 5 years following construction. The result is relatively few data on the overall performance of natural channel design […]

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Heavy Rare Earth Elements: New Insight into Mineralogical Parameters That Impact Mine Processing

Current Heavy Rare Earth Element (HREE) processing techniques are expensive, environmentally-challenging, and slow. Kinetic models predict that the rate of acid permeation of a mineral is the rate controlling step. Therefore, permeation rate controls the acid quantity and residency time of the mineral in the acid bath; impacting costs. Kinetic models are based on structural […]

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Heavy Rare Earth Elements: New Insight into Mineralogical Parameters That Impact Mine Processing – Year two

Current Heavy Rare Earth Element (HREE) processing techniques are expensive, environmentally-challenging, and slow. Kinetic models predict that the rate of acid permeation of a mineral is the rate controlling step. Therefore, permeation rate controls the acid quantity and residency time of the mineral in the acid bath; impacting costs. Kinetic models are based on structural […]

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Analysis of techno-economic-environmental feasibility of zero emission buses on public transit routes in Canadian context – Year two

Substitution of existing diesel buses by zero-emission propulsion technologies (electric batteries and hydrogen fuel cell) in vehicles – specifically public transit fleets – can play an instrumental role in realizing Canada’s obligation towards green house gas emission reduction. It is imperative to enable transit agencies to assess the capabilities of existing technology variants in meeting […]

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Optimization of astaxanthin production in large-scale cultivation of microalgae by utilizing industrial CO2 emissions

Haematococcus pluvialis is a green microalga that concentrates the compound astaxanthin, a commercial product with nutraceutical, pharmaceutical, cosmetic, aquaculture, and food applications. Astaxanthin is a carotenoid pigment with high antioxidative activity, used as a feed additive to provide a characteristic pink color to salmonids and shrimp, as well as a human nutraceutical providing protection from […]

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Optimization of astaxanthin production in large-scale cultivation of microalgae by utilizing industrial CO2 emissions – Year two

Haematococcus pluvialis is a green microalga that concentrates the compound astaxanthin, a commercial product with nutraceutical, pharmaceutical, cosmetic, aquaculture, and food applications. Astaxanthin is a carotenoid pigment with high antioxidative activity, used as a feed additive to provide a characteristic pink color to salmonids and shrimp, as well as a human nutraceutical providing protection from […]

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Advanced Hybrid Solid-State Lithium(-ion) Batteries for Electric Vehicle Applications

As the dominating power supplies for current electric vehicles (EVs), the state-of-the-art LIBs are yet sulfuring from severe challenges in terms of safety, lifespan, and energy density due to the adoption of liquid electrolytes (LEs). Accordingly, developing next generation solid-state lithium(-ion) batteries (SSLBs) is considered to be a feasible approach to achieve safe and high […]

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Advanced Hybrid Solid-State Lithium(-ion) Batteries for Electric Vehicle Applications – Year two

As the dominating power supplies for current electric vehicles (EVs), the state-of-the-art LIBs are yet sulfuring from severe challenges in terms of safety, lifespan, and energy density due to the adoption of liquid electrolytes (LEs). Accordingly, developing next generation solid-state lithium(-ion) batteries (SSLBs) is considered to be a feasible approach to achieve safe and high […]

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A melanoma diagnosis and prognosis framework with human readable explanation

Melanoma is the most lethal skin cancer, accounting for 2% of all skin cancer types, yet approximately 75% of skin cancer deaths. It often evolves from clear skin or existing moles, making it difficult to diagnose at early stage. Besides, the treatment of melanoma is a complex decision making process, which is affected by a […]

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Splicing alterations: from pathogenic variant discovery to next generation therapeutics development

Many human genetic diseases are associated with defects in post-transcriptional gene regulation and alternative splicing. Despite rapid technological advancements, successful diagnostic rates for rare genetic disorders are still low and clinical interventions and treatments unavailable for most patients. This project aims to address this challenge by developing novel antisense RNA therapies based on the splice-switching […]

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Évaluation de l’éco-efficacité par simulation de procédés dans le domaine de la transformation laitière.

Un prototype de logiciel d’évaluation de l’éco-efficacité des procédés de transformations des produits laitiers par simulation numérique de procédés industriels a été développé dans le cadre des travaux de doctorat de S. Benoit. Le présent projet vise à rendre cet outil utilisable par l’industrie laitière et à l’enrichir de fonctionnalités supplémentaires. En plus de quelques […]

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