Amyloid cardiomyopathy is an under-recognized cause of heart failure and is caused by normal proteins in the bloodstream going bad (known as amyloid) and accumulating in the heart. This accumulation of amyloid in the heart tissue causes the wall of the heart to become rigid and ineffective at pumping blood to the rest of the body, causing heart failure. We are studying a form of amyloid cardiomyopathy called immunoglobulin light chain (AL) amyloidosis, caused by the accumulation of light chain proteins.
Underground mines generate significant volumes of crushed waste rock, called tailings, but almost half of these can be returned underground and used as value-added backfill. This research uses non-destructive sensors that monitor the backfill’s strength in real time and provides operators with information needed to safely place backfill as quickly as possible. The sensors will be developed and deployed at operating mines so that they are validated under real-world operating conditions.
In order to investigate proteins in their natural environment one can attach tiny reporter molecules to them that can be traced with appropriate instruments. However, these small reporter molecules may often cause strong perturbations to the functionality of the proteins, or cannot be seen due to experimental restrictions like low concentrations. Bioorthogonal chemistry aims to eliminate such experimental restrictions by using as inert molecules as possible to see how proteins really work.
There is massive growth in the area of smart cities (e.g. sensors in streetlights), smart cars, and "smart people" (sensors on people, e.g. wearable computing). In some cities like San Diego, there are cameras and microphones in nearly every streetlight in the downtown core area. Most cars made now have one or more cameras in them, and numerous other kinds of sensors are being invented. These sensors are important regarding autonomous vehicles as well as technologies for extended human intelligence and safety.
The recent legalization of cannabis in Canada offers a unique opportunity to conduct fundamental research without the bureaucracy issues faced in other countries. The current state of cannabinoid-based therapies have focused their use in the treatment of cancer, pain, inflammation and opioid addiction, and suffer from unwanted side effects and lack of efficacy. Furthermore, the current opioid epidemic and the lack of better pain management strategies highlight the urgency for long-term solutions for chronic pain management.
This project proposes a survey directed at transit agencies in Canada that have operated, operating, or planning to operate flexible transit, with special emphasis placed on app-based on-demand transit services. Personal interviews will be conducted with key personnel at the transit agencies, likely using phone communication. The results of the survey along with a more comprehensive review of industry reports will be summarized to highlight the key practices of flexible transit in Canada.
Fungal pathogens of agriculturally significant crops pose a serious threat against global food security. This is exacerbated by the limited classes of fungicides that are commercially available for the farmers and the rapid emergence of resistance against the existing fungicides. Furthermore, resistance against agricultural fungicides can poses serious threat to human health as it can provide cross-resistance to the antifungal drugs that are used in the clinics world-wide.
To design effective and patient-specific cancer therapy, sensitive detection of relapse and distant metastases by non-invasive medical imaging is essential, for which MRI offers tremendous potential due to wide availability of the equipment in clinic and avoidance of ionizing radiation. Although gadolinium-based contrast agents are the most frequently used for MRI, they are associated with nephrogenic systemic fibrosis and brain deposition. Thus, less toxic manganese ions (Mn 2+ ) are exploited as an alternative for tumor detection using MRI.
Blood biomarkers have been an invaluable tool in concussion research. Through their use, we have improved our knowledge on the processes that occur in the brain and body following injury and have seen promise for future implementation in a clinical setting to inform injury severity, type, and treatment responses. However, many different biomarker technologies exist, and it is not clear to what extent they may differ, or whether results derived from them can be compared. Hence, validation is needed.
Presbyopia is an aging phenomenon that eventually affects 99.9% of the population and Aniridia is a rare genetic disease resulting in the absence of an iris. Currently, no treatment provides a dynamic solution for patients. We are creating a thin, flexible, biocompatible electronic device to rapidly control a bionic iris through a fast, reversible, wireless energy efficient process, providing a responsive and dynamic solution to both diseases. Successful completion of the project will significantly aid the partner organization to commercialize their device.