A mass spectrometry approach to unveil cytoplasmic bacteria interactomes

The innate immune system is the first line of defense of our body against pathogenic bacteria. It uses a sophisticated arsenal of proteins that recognize and fight infection. Certain bacteria, like the food-borne pathogen Salmonella, can enter cells in your body to hide. We recently identified novel immune sensors that allow the recognition of these bacteria in cells but our understanding of their actions remains limited. To better understand it, this project will use a powerful technique called mass spectrometry, to unveil how human proteins interact with Salmonella inside cells to initiate a healthy immune response to clear the infection. Identification of these proteins will develop key knowledge to help us develop future strategies to fight antibiotic resistant bacteria and sepsis.

Faculty Supervisor:

Leonard Foster

Student:

Partner:

University of York

Discipline:

Life Sciences

Sector:

Life Sciences (not health); Health and Related Sciences & Technology

University:

The University of British Columbia

Program: