Circulating micro-RNAs associated to the aerobic exercise cardiovascular benefits during pregnancy

Physical activity during pregnancy has been related to benefits for both, mother and fetus, mainly by improving cardiovascular health. However, molecular mechanisms involved in these adaptations are not fully described. Micro-RNAs (miRNAs) are noncoding-RNAs which may influence gene expression. miRNAs levels are altered in response to nutrition and lifestyle interventions, including exercise. Some miRNAs are related to cardiovascular health and have been established as markers of health and disease. Nevertheless, there is a gap of knowledge regarding the impact of physical activity in miRNAs and its relationship with cardiovascular health during pregnancy. The aim of this project is to determine the association between miRNAs and the benefits of aerobic exercise on cardiovascular health during pregnancy. We expect to find an association between changes in miRNAs levels such as miR-21, miR-146b-5p, miR-210, miR222, and miR517-5p, and maternal cardiovascular health in women who exercise during pregnancy.

Faculty Supervisor:

Margie Davenport

Student:

Partner:

Universidad de O'Higgins

Discipline:

Life Sciences

Sector:

Education

University:

University of Alberta

Program: