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Correlation of multiple antibiotic resistance with biofilm-formation ability and the role of RpoS on biofilm formation in environmental E. coli
Bacterial contamination of fresh waters is a concern for the Great Lakes region.
Contamination can be prevalent due to direct faecal deposits, as well as environmental
conditions, such as sand, serving as a reservoir. One of the major contributors to bacterial
persistence in the environment is the formation of multicellular biofilms. RpoS, a general
stress response sigma factor, likely has a positive function in biofilm formation, but RpoS in
environmental isolates is also subject to loss through mutation and selection. This project
aims to identify a putative correlation between multiple antibiotic resistance and biofilmformation
ability, as well as the effect of RpoS on biofilm in environmental E. coli strains.
Because the partner organization (Environment Canada) works on multiple antibiotic
resistance for microbial-source tracking and has previously collaborated with us on work
related to RpoS, this project is a natural extension of earlier work.
Faculty Supervisor:
Herb Schellhorn
Student:
Partner:
Environment Canada (Burlington, ON)
Discipline:
Life Sciences
Sector:
University:
McMaster University
Program:
Accelerate
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