Development of mass spectrometry-based metabolomics to explore the chemical complexity of cannabis

The medical cannabis industry in Canada is at the forefront of cannabis research, yet it faces significant challenges due to the plant’s complex chemical composition, including numerous cannabinoids, terpenes, flavonoids, and other bioactive compounds. Currently, cannabis prescriptions often rely on limited clinical data, leading to inconsistent therapeutic outcomes. This project addresses these challenges by developing an advanced metabolomics approach using state-of-the-art liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). By comprehensively profiling both volatile and non-volatile cannabis compounds, we aim to map the full chemical diversity of cannabis cultivars. This metabolomics-driven strategy will enable a more precise, evidence-based classification of cannabis strains, improving clinical decision-making and patient outcomes. Additionally, the project will produce innovative bioinformatics tools for accurately identifying metabolites, linking chemical profiles to therapeutic effects. This research bridges analytical chemistry and clinical medicine, advancing Canada’s leadership in medical cannabis research and supporting better health outcomes.

Faculty Supervisor:

Tao Huan

Student:

Partner:

Controlled Chemistry

Discipline:

Life Sciences

Sector:

Agriculture

University:

The University of British Columbia

Program: