Directly reprogrammed neural precursor cell transplants to treat chronic stroke

Stroke is one of the leading causes of acquired long-term disability worldwide. There are >60,00 thousand new cases of stroke each year and >400,000 patients currently living with chronic disabilities. There are limited interventions to treat the acutely stroke injured brains and no treatments to improve the chronic condition. Herein, we will explore the efficacy of a safe and clinically relevant population of directly reprogrammed human neural precursor cells (drNPCs) to treat chronic stroke. We will perform our studies in a model of photothrombotic stroke (PT) that leads to sustained functional deficits to mimic the chronic condition in humans. Based on previous studies using drNPCs in neural regenerative approaches, we hypothesize that drNPCs will enhance brain neuroplasticity and support improved functional outcomes, the most important measure of success. Chronic stroke is understudied, and our work will provide insight into neural reparative approaches for patients that currently have no treatment options.

Faculty Supervisor:

Cindi M Morshead

Student:

Partner:

New World Laboratories Inc

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: