Dynamic Proteomic Profiling During Skeletal Muscle Loading and Unloading in Humans

Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an increased risk of frailty and becoming insulin resistant. Some individuals fail to increase the size of their muscle following (low responders) whereas others show vary large increases in muscle size (high responders) in response to the same resistance training program. People also show differences in the amount of muscle tissue they lose when they have a limb immobilized (i.e., leg casted, or leg brace). However, the molecular mechanisms driving changes in muscle size remain poorly understood. Recent methodological advances might allow us to uncover molecular mechanisms that govern changes in muscle size. Using an innovative methodology, the purpose of my Gloablink research project is to implement a novel methodology designed to discover key regulators of muscle size in humans.

Faculty Supervisor:

Stuart Phillips

Student:

Partner:

University of Nottingham

Discipline:

Life Sciences

Sector:

Education

University:

McMaster University

Program: