Effects of joint loading on immune cell populations at the healing ACL tendon graft-to-bone interface

The anterior cruciate ligament (ACL), one of the major ligaments maintaining stability of the knee, is frequently injured. Afterwards, a surgical reconstruction using a tendon graft is typically used to restore stability and allow individuals to achieve improved levels of mobility. Reconstruction involves taking a portion of tendon from elsewhere in the body and guiding/securing it through bone “tunnels” in the knee to approximate the original ACL. One of the critical factors determining the success of this surgery is the ability of the graft tissue to integrate with adjacent bone. The biology and mechanics of this process remain largely unknown. This project aims to reveal the healing process as it relates to the key cell types involved as well as to mechanical load to the joint. The results of the study have the potential to identify therapeutic targets and rehabilitation regimens that will improve graft-to-bone healing.

Faculty Supervisor:

Samer Adeeb

Student:

Partner:

Weill Cornell Medical College The Rockefeller University

Discipline:

Life Sciences

Sector:

Education

University:

University of Alberta

Program: