Effects of Metal Ions on Biological Membranes and Cellular Systems

Heavy metal toxicity has been a cause for public health concern for decades. There are a variety of industries that both produce heavy metals as a byproduct, or use them directly in consumer products or practical applications. In particular, cadmium (Cd) is one such toxic metal that is known to induce negative effects not only on cellular systems, but to organs as a whole. Cd is a known carcinogen, and can impart cellular toxicity through a number of biochemical pathways. While some of these pathways, such as DNA damage, production of reactive oxygen species (ROS), and inhibition of apoptosis are well categorized; the effects of Cd at the level of cellular membranes are less well known. Cellular and organellar membranes not only provide key structural platforms, but also serve as signalling platforms and act as interfaces between cells and between organelles. To understand the mechanisms by which Cd may induce damage to these crucial structures is key to completing a full outlook on the potential dangers associated with Cd toxicity.

Faculty Supervisor:

Elmar Josef Prenner

Student:

Partner:

Witten/Herdecke University

Discipline:

Physics

Sector:

Life Sciences (not health); Environmental Science and Technology; Health and Related Sciences & Technology

University:

University of Calgary

Program: