Electrophysiological Effects of Physiological Antibodies and Autoantibodies on Neuronal Function

This project is a continuation of my doctoral research, which investigates how IgG antibodies interact with neurons in various neuropathological conditions. So far, weve observed that IgGs can be internalized by neurons in models of spinal cord injury, stroke, and neuropsychiatric lupus (NPSLE). The next critical step is to understand the physiological consequences of this internalization. This project will explore how IgGsboth normal and autoimmuneaffect neuronal activity using electrophysiological techniques. This includes measuring changes in spontaneous activity (such as resting potential and firing rate) and evoked responses (like input/output curves and synaptic currents) in primary cultures of cortical, dorsal root ganglion (DRG), and trigeminal ganglion (TG) neurons. These experiments will help determine whether IgGs disrupt neuronal signaling and could reveal shared mechanisms across CNS disorders. As disruptions to the brains immune barriers are increasingly implicated in conditions ranging from traumatic injury to mood disorders, understanding how antibodies interact with the CNS is essential. By uncovering these mechanisms, the project may help identify new therapeutic targets and contribute to better treatment strategies.

Faculty Supervisor:

Éric Boilard

Student:

Partner:

Université Côte d'Azur

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

Université Laval

Program: