Exploring Thalamo-Prefrontal Cortex Connectivity: A multimodal analysis using cutting-edge neuroimaging and a high-resolution histology-based atlas

The prefrontal cortex (PFC), the front part of the brain, plays a crucial role in high-level cognitive functions such as self-awareness, working memory, problem-solving, and emotional regulation. Damage to this region can lead to significant personality changes, as famously illustrated by the case of Phineas Gage, an American railworker in the 19th century who survived a severe brain injury but experienced profound alterations in his personality. These complex functions are supported by diverse microanatomical properties and dense connectivity to other brain regions. One of the PFC’s key connections is with the thalamus, a deep located brain structure known as the “gateway” for multiple functions. The thalamus acts as a central hub that receives and relays motor, visual, auditory, somatosensory, and other types of information to and from various regions, including the PFC.
Our project aims to explore the structural connectivity and underlying cortical properties of the thalamo-PFC circuitry using advanced MRI techniques, high-resolution histological data, and detailed brain maps. This research will enhance our understanding of how these connections support complex cognitive processes.

Faculty Supervisor:

Alan Evans

Student:

Partner:

Forschungszentrum Jülich

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

McGill University

Program: