Exploring the Potential of Chitosan and Chitosan-Lipid Complexes as Adjuvants and Delivery System in Vaccine Development: A Systematic Screening and Evaluation Study

Vaccines are essential in protecting individuals from infectious diseases by preparing their immune systems to recognize and combat pathogens. The tremendous impact of vaccines on public health cannot be emphasized enough, as they have saved countless lives since their inception. However, the adaptability of viruses and other infectious agents has necessitated the development of new vaccine strategies. Genetic material-based vaccines have emerged as a promising approach, offering improved design and immune responses. Nevertheless, these vaccines require adjuvants to maximize their effectiveness. This research project focuses on exploring the potential of chitosan, a natural biopolymer, as an adjuvant. Chitosan possesses immune-stimulating properties, and its cationic nature and chain length might influence its effectiveness. Additionally, the project aims to develop a delivery system platform utilizing hybrid chitosan/lipid nanoparticles. This platform would serve the dual purpose of delivering nucleic acid and stimulating the immune system.

Faculty Supervisor:

Marc Lavertu

Student:

Partner:

RNA Technologies & Therapeutics Inc.

Discipline:

Engineering

Sector:

Pharmaceuticals; Nanotechnology; COVID-19 related Research and Solutions

University:

Polytechnique Montréal

Program: