Exploring the urinary microbiome during kidney transplantation

In this research project, we aim to explore the role of the bacteria living within the urinary tract, or the urinary microbiome, during kidney transplantation. Using urine samples from human kidney transplant recipients and donors, we will use bacterial gene sequencing to determine how the urinary microbiome changes over time and during rejection of the transplanted kidney. We will also perform studies in mice to determine if and how several transplant-related factors such as immunosuppressant medications, kidney injury, and graft rejection cause changes to the microbiome. These studies will lay the foundation for future study of the microbiome as a potential clinical tool in the diagnosis of transplant outcomes and/or as a target for therapeutic interventions. We anticipate that our findings will eventually contribute to improving the outcomes of kidney transplantation and maximizing the life of each transplant patient.

Faculty Supervisor:

David Harriman;Dirk Lange

Student:

Partner:

Provincial Health Services Authority

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Information and cultural industries; Professional, scientific and technical services; Public administration

University:

The University of British Columbia

Program: