Discover more projects across a range of sectors and discipline — from AI to cleantech to social innovation.
Breast cancer (BC) accounts for 15% of all cancer cases in Ontario, affecting 8,700 women in 2009. Thus, there is a great need for the development of new anti-cancer agents and the identification of patients who are best suited for tailored treatment. The drug metformin has emerged as a potential therapy for BC. Metformin is commonly used to treat type 2 diabetes, but clinical studies have demonstrated that it can inhibit BC. However, it is unclear how metformin inhibits BC and which patients would be most suitable for metformin therapy. Therefore, the goal of the project is to determine how metformin reduces BC and to design ways to identify patients who would most benefit from metformin treatment. The results of this study will be critical for the identification of women in Ontario and across Canada, who would most benefit from metformin treatment. The results of this study will be critical for the identification of women in Ontario, and across Canada, who would be most responsive to metformin based BC therapies.
Dr. Vuk Stambolic
University of Toronto
Find the perfect opportunity to put your academic skills and knowledge into practice!Find Projects
The strong support from governments across Canada, international partners, universities, colleges, companies, and community organizations has enabled Mitacs to focus on the core idea that talent and partnerships power innovation — and innovation creates a better future.