In Vitro study of the anti migration and anti metastasis proprieties of Carnosol on oral cancer

Oral cancer is one of the most aggressive forms of cancer, and the incidence of new cases and mortality is rising worldwide. Currently, oral cancer is treated with chemotherapy agents alone or in combination with radiotherapy or surgery. Chemotherapeutic approaches made the patients suffer from severe side effects and drug resistance. Henceforward, the current focus is leaning towards using plant-derived compounds (also called phytochemicals) as they have lower cost, exhibit less toxicity, are more effective, and with reduced adverse effects. Several phytochemicals displayed anticancer activity, because they target several molecular pathways including apoptosis, proliferation, cancer stem cells, inflammation, invasion, metastasis and angiogenesis. Carnosol, a naturally occurring phytopolyphenol found in sage, oregano and rosemary, has been shown to inhibit cellular viability, colony growth, induced cell cycle arrest, autophagy, and apoptosis in various types of cancer. Nonetheless, exploring its mechanisms of action, alone or in combination with a chemotherapeutic agent, can serve as a potential tool to decimate oral cancer.

Faculty Supervisor:

Abdelhabib Semlali

Student:

Partner:

Lebanese University

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Pharmaceuticals; Biotechnology

University:

Université Laval

Program: