Investigating the dose-response of prenatal-THC exposure in adolescent mice

Across the world, rules regarding the legalisation of recreational use of cannabis are changing. This is leading to a perception that cannabis is safe to use: people remain unaware of consequential health risks. The concentration of delta-9-tetrahydrocannabinol (THC), often found in cannabis products, is rising – a concern as THC is known to have psychoactive effects. Furthermore, it has been shown that maternal and paternal cannabis use during pregnancy increases the risk of psychotic-like experiences in offspring. This alongside the substantial neurodevelopmental basis of such disorders, could, therefore, result in an emergent risk of psychotic disorders within the population. Since cannabis/cannabis products are additionally being used to counteract nausea in pregnancy, it is imperative that studies addressing this are carried out sooner rather than later. This project will investigate dose-dependent effects of prenatal-THC exposure on the neurodevelopment of offspring during adolescence in rodents. Scientific data collected may provide knowledge to guide policies aimed to prevent future public health challenges.

Faculty Supervisor:

Mallar Chakravarty

Student:

Partner:

University of Oxford

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Other

University:

McGill University

Program: