Investigating the effect of disease-causing TRNT1 mutations on cellular stress response: a pathway to treatment.

The proposed project aims to investigate the link between tRNA maturation and mitochondrial disease using yeast as a model system. Researchers from Carleton University in Canada will collaborate with experts from Comenius University in Slovakia to develop advanced gene-tagging techniques in yeast. This collaboration will allow for the creation of new reagents, tools, and technologies to study the pathophysiology of TRNT1 (CCA1) deficiency, a condition related to mitochondrial diseases. The project is expected to benefit both participating institutions by fostering international research collaboration, enhancing innovation capacity, and providing new insights into mitochondrial disease processes. The Canadian team will gain access to specialized expertise and techniques in yeast molecular biology, while the Slovak team will benefit from the Canadian researchers’ experience in translation regulation and disease modeling. This cross-cultural scientific exchange will not only advance scientific knowledge in the field of mitochondrial diseases but also strengthen the research capabilities of both institutions, potentially leading to future joint grant applications and publications.

Faculty Supervisor:

Martin Holcik

Student:

Partner:

Comenius University

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Life Sciences (not health)

University:

Carleton University

Program: