Investigating the mechanism of theta burst stimulation

Transcranial magnetic stimulation (TMS) is a safe form of non-invasive brain stimulation that treats different brain conditions. Theta burst stimulation (TBS) is a TMS protocol that alters the underlying neural circuitry and is an FDA and Health Canada approved treatment for Major Depressive Disorder. How cTBS changes brain function remains unknown; however, understanding this mechanism is important to improve ongoing mental health treatments. The objective of the research project is to determine how a TBS protocol called continuous TBS (cTBS) changes targeted brain networks. This project will use medications that can block or enhance neuronal processes during the administration of a cTBS session, which helps determine the underlying mechanism of TBS. Participants will be randomized into two groups to receive different medications with active and placebo cTBS. Before and after stimulation, participants will undergo an electroencephalography (EEG) and a cognitive test of working memory. EEG measures electrical brain activity and reveals changes in neurophysiology. The working memory test can indicate changes in cognitive function. Understanding how brain stimulation mechanisms impact biology and behaviour supports the ongoing research at the University of Calgary and McLean Hospital of Harvard Medical School, which aims to improve neurodevelopmental and neuropsychiatric treatment options.

Faculty Supervisor:

Kara Murias

Student:

Partner:

Harvard University

Discipline:

Life Sciences

Sector:

Education

University:

University of Calgary

Program: