Microfluidics Lab on a Chip device

There is no definite knowledge about how cells transforms and responds to the physical forces in human body. Recent studies shows that chemical signals, environment as well as mechanical properties can steer the cell behavior. Recent advancement in MEMS and micro fabrication techniques leads to the ability to study biological responses using a lab on a chip and organ on a chip devices. The potential to mimic exact same cellular level conditions made LOC a vibrant and rapidly-progressing field. Mechanotransduction can be studied in details by placing the cells in a micro porous membrane and applying a uniaxial stretch. Recent research solved the challenges to create a biaxial stretch which is more close to biological force condition compared to the uniaxial. Our objective of this research is to develop a micro fabricated multi axis stretching LOC device for studying mechanotransduction and biomedical applications.

Faculty Supervisor:

Chris Zhang

Student:

Partner:

Shanghai University

Discipline:

Engineering

Sector:

Education

University:

University of Saskatchewan

Program: