In the CNS the majority of excitatory synapses are formed onto specialized structures known as dendritic spines which can undergo shape changes in the time frame of minutes to days. This inherent structural plasticity of dendritic spines even lasts into adulthood. It is still unclear why certain spines are more likely to be maintained, to provide a physical substrate for long-term information storage, while others are more structurally plastic. We have recently discovered a novel process by which mature dendritic spines can be maintained. The objective of the proposed study is to continue to contribute to the understanding of the rules that regulate the morphology and function of dendritic spines and develop novel targets for learning disorders.
Rebecca Anne McKinney
SERGIO VILLICANA MUNOZ
Pharmacy / Pharmacology
Find the perfect opportunity to put your academic skills and knowledge into practice!Find Projects
The strong support from governments across Canada, international partners, universities, colleges, companies, and community organizations has enabled Mitacs to focus on the core idea that talent and partnerships power innovation — and innovation creates a better future.