NeuroCSF: development of a novel fMRI method to measure contrast sensitivity function in the amblyopic visual cortex

This research project centers on exploring the Contrast Sensitivity Function (CSF), a fundamental concept in visual perception that determines the perception of spatial frequencies at varying contrast levels. Existing CSF measurement methods relying on behavior are constrained by time and patient-related factors, necessitating an alternative approach. To address this challenge, we introduce the “neuroCSF,” which utilizes functional Magnetic Resonance Imaging (fMRI) to directly estimate the CSF from brain activity, bypassing the need for behavioral data. In our initial assessment, the neuroCSF demonstrated robust and interpretable estimates of cortical CSF parameters, marking a groundbreaking achievement in comprehensive CSF characterization. Moving forward, our research aims to expand the neuroCSF methodology to clinical populations, with a particular focus on amblyopia, a neurodevelopmental visual disorder. With this current project, we aim to identify neurometrics that correlate with the reduced behavioral CSF measures in amblyopes. Collaboration with Dr. Miguel Castelo-Branco and Coimbra Institute for Biomedical Imaging and Translational Research will provide access to advanced imaging resources and essential clinical expertise that are central to our efforts. The application of fMRI to create a comprehensive visuocortical map of the CSF holds great promise for improving amblyopia diagnosis and deepening our understanding of the disorder’s underlying mechanisms

Faculty Supervisor:

Reza Farivar-Mohseni

Student:

Partner:

Universidade de Coimbra

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

McGill University

Program: