New 2-amino-4-arylimidazole derivatives mimic the core structure of some marine alkaloids

The results obtained in this project will lead to new tools for the preparation of molecules of interest, possibly with biological activities. These studies will contribute to the development of new green synthetic methods using environmentally friendly catalysts.
Efficient and practical synthetic methods are in high demand in the industrial and academic sectors. In particular, the pharmaceutical sector is highly interested in new efficient preparations of small organic molecules as high added-value building blocks.
This work aims to synthesize potentially biologically active compounds that mimic metabolites of marine sponges. The project under consideration has an actual pharmacological use. Firstly, the specific synthetic scheme as a general procedure will facilitate the work of both chemists and pharmacologists. Secondly, expected biologically activities of the obtained substances have a wide range of applications. The most important activities of them: antitumor, antibacterial, antihistamine, fungicidal. It is also known about the ability of substituted 2-aminoimidazoles to inhibit human ?-secretase (BACE1), NO-synthase and act as tubulin-binding agent. Thirdly, this research opens new routes for the synthesis of heterocyclic compounds, which are known to play an important role in pharmacy. The present project is a step towards the discovery of many essential drugs.

Faculty Supervisor:

Thierry Ollevier

Student:

Partner:

National University of Kharkiv

Discipline:

Life Sciences

Sector:

Pharmaceuticals; Life Sciences (not health); Sustainability & the Environment

University:

Université Laval

Program: