Nickel-catalyzed [3+2+1] synthesis of 2-pyridones

Catalysts speed up chemical reactions by lowering the energy required for a process to occur. In our daily lives, this phenomenon occurs very similarly to how catalytic converters in car exhausts work. By employing a catalyst, we can minimize waste and save energy, time, and money. However, to increase the performance of a catalyst, and to discover the most efficient process, one must know how the catalyst works. Building upon previous research, we envision a novel methodology in which minuscule quantities of nickel can be used to discover new ways of making useful nitrogen-containing molecules. We will investigate the efficiency of this process whilst trying to improve this new method. We hope that this new technology can be used to synthesize versatile building blocks as valuable pharmaceutical intermediates.

Faculty Supervisor:

Jeremy Wulff

Student:

Partner:

Osaka University

Discipline:

Physics

Sector:

Education

University:

University of Victoria

Program: