Phagocytosis of asbestos and macrophage dysfunction.

Asbestos was once used extensively in the fabrication of a variety of products and materials. After being declared a carcinogen and linked with a variety of lung diseases more than 2 decades ago, the use of asbestos was banned in many countries. Yet, asbestos remains a public health concern worldwide and one of the leading causes of occupational deaths in Canada. The molecular and cellular mechanisms underlining asbestos pathogenic effects are poorly understood. The objective of this research project is to conduct an in-depth characterization of the phagocytosis of asbestos fibers in lung macrophages and determine the possible contribution of asbestos surface chemistry on the disruption of phagocytosis and macrophage dysfunction. Utilizing state of the art microscopy technologies combined with cell biology techniques, we will characterize the maturation stage of asbestos fibers-containing phagosomes inside lung macrophages and investigate its deleterious effects on cell membranes. Findings coming out from this research will aid to better comprehend mechanisms by which asbestos persists in the lung and causes disease and will foster opportunities in diagnostic and therapeutic interventions promoting lung health in the affected individuals.

Faculty Supervisor:

Mauricio Terebiznik

Student:

Partner:

Universidad Juan Agustín Maza

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Other

University:

University of Toronto

Program: