PI3K-dependant regulatory B cells in immunity

Our research focus is to understand the function of the PI3K family of enzymes, and the intracellular signals they produce, in immune system defenses and regulatory functions. Our specific aim is to understand how the dynamics of immune responses generated by B cells are controlled by these signaling enzymes to produce protective or ineffective immune responses in the context of specific infectious diseases. Folayemi’s studies have shown that there is unexpectedly improved control of early infection when PI3Kdelta enzyme activity is defective. The research of Professors Marshall (Winnipeg) and Okkenhaug (Cambridge UK) have converged in identifying PI3Kdelta-dependent regulatory B cells as critical regulators of the immune response to various infections. Collaborative work will combine expertise, novel concepts, animal models and immunological analyses developed in the UK and Canada. This Globalink award will support PhD student Folayemi Adefemi to visit Cambridge from April-June 2021 to perform laboratory research related to the collaboration, and additional exchange of a UK student to Winnipeg is planned.

Faculty Supervisor:

Aaron Marshall

Student:

Partner:

University of Cambridge

Discipline:

Life Sciences

Sector:

Education

University:

University of Manitoba

Program: