Separation of Heterogeneous Biological Samples Using a Tangential Flow Filtration Microfluidic Device

This work suggests an innovative microfluidic approach for complex biological sample separation, emphasizing the need for methods that enhance efficiency while considering the delicate nature of such samples. This project aims to deploying a continuous, portable microfluidic sorter that can effectively process heterogeneous organoid samples, enhancing throughput and preserving sample integrity. The findings will contribute to more efficient biomedical research and applications, paving the way for advancements in personalized medicine and drug discovery. The completion of this project is dependent upon 2 main objectives: 1) Redesigning and assembling the tangential microfluidic sorter based on the specific characteristics of the provided sample (such as size, shape, and density), optimizing the flow rates and sample buffer solutions respectively. 2) Testing the microdevice performance with real biological samples and assessing their viability. Biological testing will be further carried out to determine key biological questions. Successful implementation of this device would validate the effectiveness of this approach and demonstrate its versatility and true tunability to adapt and separate a wide variety of size ranges .

Faculty Supervisor:

Pouya Rezai

Student:

Partner:

University of Technology Sydney

Discipline:

Engineering

Sector:

Education

University:

York University

Program: