Synthesis of Cell-Permeable Copper Chelators for Detecting, Sensing, and Therapy

For this new international collaboration we plan to develop cell-permeable metal binding agents as therapeutics to treat Wilson’s disease. Wilson’s disease is a genetic disorder that results in the build-up of excess copper in the liver, leading to significant toxicity. By drawing on the expertise of the research teams in Canada and Brazil we plan to synthesize new agents that selectively target excess Cu in the liver, and then test the effectiveness of these compounds in a cell model of the disease. Our eventual goal is to develop drug candidates that effect the removal and normalization of copper levels in the liver.

Faculty Supervisor:

Tim Storr

Student:

Partner:

Universidade Federal de Minas Gerais

Discipline:

Physics

Sector:

Education

University:

Simon Fraser University

Program: