Synthesis of transition-state inhibitors of galactofuranosyltransferase 2

The project aims to prepare transition-state inhibitors of the enzyme galactofuranosyltransferase 2 (GlfT2), on purpose to find a potential treatment against tuberculosis. Tuberculosis is still one of the worldwide deadliest infectious disease and drug resistance cases are rising.

In humans, most tuberculosis infections are caused by the bacteria Mycobacterium tuberculosis (Mtb). Gft2 enzyme is involved in the construction of the mycobacteria cell walls wich are paramount for each bacteria cell survival in his host. Futhermore, there are no efficient inhibitors for the GfT2 enzyme reported.

This project will be focused on the development of multi-step synthesis strategy on purpose to obtain the desired inhibitor and its analogues. Once the inhibitors prepared and characterized, each one of them will be tested in vitro in France, at the CNRS of Rennes.

Faculty Supervisor:

André Pichette

Student:

Partner:

Victoria University of Wellington

Discipline:

Physics

Sector:

Education

University:

Université du Québec à Chicoutimi

Program: