Temporal Interference Stimulation in the Rhesus Macaque

Deep brain stimulation is a treatment method for Parkinson’s Disease, involving implanting an electrode deep into the brain. This procedure has a small but serious risk of complications such as hemorrhage and infection. However, a new stimulation technique, called temporal interference stimulation, may circumvent these risks, and allow for non-invasive deep brain stimulation. Temporal interference stimulation can selectively target deep brain structures in the mouse, however whether it will work in larger animals is currently unknown. This project aims to test whether temporal interference stimulation will be able to activate deep brain structures in a larger animal that is more similar to humans. The findings will provide insights into whether temporal interference stimulation will be a feasible approach for deep brain stimulation in humans. The research findings and resulting articles from this research project will help PSSO with communicating results to the community and attract new donors.

Faculty Supervisor:

Brian Corneil;Lyle Muller

Student:

Partner:

Parkinson Society Southwestern Ontario

Discipline:

Life Sciences

Sector:

Other services (except public administration)

University:

The University of Western Ontario

Program: