The anti-Helicobacter pylori properties of probiotic lactobacilli secretomes

Helicobacter pylori is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current snit- H. pylori treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner. Using the released molecules also facilitates determining the mechanism of action. We propose to compare the secretions produced by 24 Lactobacilli for their anti-H. pylori effects, determine their mechanisms of action and identify the nature of the active molecules. This will allow the development of effective formulations that could be used to treat patients or prevent infections.

Faculty Supervisor:

Carole Creuzenet

Student:

Partner:

Lallemand Bio Ingredients

Discipline:

Life Sciences

Sector:

Manufacturing

University:

Western University

Program: