The cellular-molecular landscape of the living human hippocampus

The human brain consists of more than 100 billion cells, many with specific structures and functions, performing complicated computations every day. Understanding these properties is a key component for the development of therapies for neurological disorders such as epilepsy, depression and brain tumours. So far, most of our knowledge of the human brain has been informed by model organisms engineered to replicate parts of the human brain. However, these studies do not fully capture the unique and complex properties of the human brain.
For our proposed project, we will use surgically removed brain samples from patients suffering from epilepsy. As part of one of very few laboratories worldwide with access to these precious samples, we will use cutting-edge methods and technology to identify gene-expression differences in individual cells. Leveraging this cellular-resolved access and knowledge, will help us identify new mechanisms involved in epilepsy, and develop novel therapeutic strategies.

Faculty Supervisor:

Mark Cembrowski

Student:

Partner:

Universität Bremen

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

The University of British Columbia

Program: