Uncovering genetic interactions of the translesion synthesis pathway: targeting DNA repair mechanisms as a therapeutic strategy in cancer

This project investigates how different genes involved in DNA repair work together to keep cancer cells alive. We’re focusing on a specific process called translesion synthesis (TLS), which helps cells bypass damage in their DNA. By understanding these genetic interactions, we hope to identify new ways to target and kill cancer cells, especially those that have become resistant to standard treatments. This research will benefit both Canadian and Japanese research institutions by providing new insights into cancer biology, fostering international collaboration, and potentially leading to the development of new cancer therapies.

Faculty Supervisor:

Peter Stirling

Student:

Partner:

Tokyo Metropolitan University

Discipline:

Life Sciences

Sector:

Education

University:

The University of British Columbia

Program: