Uncovering novel genetic interactions for fungal adhesins and implications for virulence

Combating infectious disease pathogens is a pressing global health challenge. Due to limited treatment options, fungal pathogens pose a unique challenge, and are emerging as a leading cause of human mortality. Focusing on Candida albicans, the most common cause of fungal infections, our research project aims to understand how different genetic factors play a role in the virulence of fungal pathogens and the progression of fungal infectious disease. We will use a worm model for infectious disease that was been developed and optimized by the host laboratory (Dr. Natasha Kirienko), and screen >100 fungal genetic mutant strains (generated by Dr. Rebecca Shapiro’s laboratory) to establish which genetic factors play an important role in virulence and survival of the worm host. Together this work will yield novel insight into the genetic mechanisms by which Candida species cause life-threatening disease.

Faculty Supervisor:

Rebecca Shapiro

Student:

Partner:

Rice University

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Biotechnology

University:

University of Guelph

Program: