Using chemokines to enhance DC-based cell therapy

Immune therapies for cancer are in their early stages and require further investigation to improve their function. Chemokines and their receptors are responsible for directing white blood cells to various parts of the body. Because they are so important in controlling the immune response, they make ideal targets for therapy. To exploit this, we aim to use these receptors to identify cells that are ready to migrate and investigate the effect these cells have on tumour growth We expect that the cells which are more suited to moving to lymph nodes will be better at inducing an immune response capable of controlling tumour growth. Therefore, we suggest that using these cells as a therapy will result in smaller tumours. These tumours will also contain an increased number of white blood cells which are better equipped for killing the cancer cells.

Faculty Supervisor:

Michael JH Ratcliffe

Student:

Partner:

University of Glasgow

Discipline:

Life Sciences

Sector:

Education

University:

University of Toronto

Program: