The Fisheries and Marine Institute of Memorial University is partnering with Grieg Seafood Newfoundland to provide 9 internships to students from the Advanced Diploma in Sustainable Aquaculture graduating class of 2021. The proposed project seeks to provide HQPs to assist Grieg in optimizing the novel equipment and systems that will be installed in their land-based […]

Antibody Drug Conjugates (ADC) are an emerging class of drugs that combine antibodies and a drug payload. The antibody cargoes the drug payload to specific targeted cells improving both safety and efficacy. To date that are 8 FDA approved ADC drugs all for oncology application using small molecule drugs. Although these ADCs with small molecules […]

It is essential to develop a vaccine against SARS-CoV-2, the virus causing the global COVID-19 pandemic. The most efficient vaccines are built on attenuated live viruses, which can be engineered to display specific antigens and, once administered in humans, can safely induce an immune response and immunity to the disease of interest. Fast, reliable, and […]

Transcription factors (TF) are proteins that drive and maintain cellular functions by physically binding to DNA and regulating the expression levels of other genes. There are approximately 1,600 TFs in the human genome. Accurate and scalable identification of TF binding locations across the entire genome remains a major challenge. An effective solution to this problem […]

Hypoglycemia or low blood sugar is a phenomenon that results from excess insulin or strenuous exercise in diabetic patients. If untreated, this can quickly lead to dizziness, seizures and even death. In healthy individuals, the body is able to compensate for these fluctuations and restore blood sugars to normal levels by lowering insulin and raising […]

CRISPR/Cas9 is a promising tool for genome engineering in bacteria, but it’s limited by inconsistent accuracy. Though some studies have been conducted to understand why this inconsistency occurs, many important biological features have not been explored. Moreover, computer based attempts to predict accuracy have suffered from these knowledge gaps. This is due mainly to the […]

The most recent breakthroughs in cancer treatment are based on understanding that our immune system can be activated to attack tumours. While first achieved using antibody drugs called “checkpoint inhibitors”, this new paradigm of activating a cancer patient’s own immune system is also possible using viruses, an emerging field known as oncolytic virus (OV) therapy. […]

Cannabidiol, is a non-intoxicating cannabinoid has anecdotal and preliminary evidence as a treatment for pain, anxiety, nausea and seizures. This project aims to identify the configuration of CBD when bound in the brain. We will use established computational techniques that have not been applied to CBD binding to calculate the pose that CBD adopts when […]

The COVID-19 pandemic is unlike anything the world has seen in over a century, both in terms of global spread and economic impact. Certain individuals particularly the elderly and those with underlying diseases, are more susceptible to severe infection and dysregulation of the immune system. Since the recent outbreak, many more individuals have been taking […]

Stroke is the number one cause of adult disability in the world. Due to the neurological damage from stroke, a vast majority of individuals suffer from hand function disability (~70%). To improve hand function and overcome challenges from this disability, IRegained has developed the MyHandTM system, a connected mechatronic device with programmed proprietary hand function […]

Our project will use genomics to help understand how climate change and land use are impacting the coupled population dynamics of Canada lynx and snowshoe hares in boreal forests. The lynx-hare cycle is a key process regulating biodiversity the boreal forest food webs, which are increasingly under threat from climate-driven increases in wildfire, insect pests, […]

Breast cancer is the fourth most frequent cancer in Canada, and affects one in X women during their lifetimes. A variety of different treatments have been tried, some of which damage cellular DNA of the quickly growing cancer cells. High-level DNA damage causes cells to die, and can shrink the tumour and arrest cancer growth. […]